Adult Stem Cell Awareness

November 22, 2008

Positive Results for Aldagen’s ALD-301 Clinical Trial

Filed under: adult stem cell awareness,alternative sources — chelseaz @ 12:04 am

aldagenAldagen announced some positive results for its multicenter Phase 1/2 clinical trial of ALD-301 for the treatment of critical limb ischemia.

In the 24-week Phase 1/2 trial, ALD-301 was well tolerated. Importantly, the study results also indicated that during the 12-week efficacy assessment period, there were improvements in overall clinical status as well as increased blood flow in the affected limb in the group of patients treated with ALD-301.

ALD-301 is the population of stem and progenitor cells that are produced using Aldagen’s proprietary technology to sort a specified quantity of bone marrow collected from the patient receiving the therapy. To produce ALD-301, Aldagen receives 150 milliliters of bone marrow extracted from the patient. At Aldagen’s manufacturing facility, Aldagen processes the bone marrow to isolate and capture the key stem and progenitor cells. Typically within 36 hours of receipt of the bone marrow, Aldagen delivers the resulting ALD-301 cells either to an interventional cardiologist or to a vascular surgeon, who then administers ALD-301 to the patient by intramuscular injection into the patient’s leg. Aldagen’s technology isolates specific populations of adult stem cells that express high levels of aldehyde dehydrogenase (ALDH-bright cells). Preclinical studies conducted by leading research institutions and academic centers have shown that ALDH-bright cells from bone marrow promote the repair of ischemic tissue damage, which is tissue damage caused by inadequate blood flow resulting from the obstruction of blood vessels supplying blood to the tissue.

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